Structure-Guided Identification of C3d
نویسندگان
چکیده
منابع مشابه
Structure-guided identification of C3d residues essential for its binding to complement receptor 2 (CD21).
A vital role for complement in adaptive humoral immunity is now beyond dispute. The crucial interaction is that between B cell and follicular dendritic cell-resident complement receptor 2 (CR2, CD21) and its Ag-associated ligands iC3b and C3dg, where the latter have been deposited as a result of classical pathway activation. Despite the obvious importance of this interaction, the location of a ...
متن کاملEpitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface.
Complement receptor type 2 (CR2)/CD21 is a B lymphocyte cell membrane C3d/iC3b receptor that plays a central role in the immune response. Human CR2 is also the receptor for the EBV viral membrane glycoprotein gp350/220. Both C3d and gp350/220 bind CR2 within the first two of 15-16 repetitive domains that have been designated short consensus/complement repeats. Many mAbs react with human CR2; ho...
متن کاملروش جدی جستجوی C3d متصل به گلوبول های قرمز در جریان فعالیت مکمل
زمینه: اخیرا اندازه گیری محصولات فعالیت مکمل برای بررسی دقیقتر فعالیت این سیستم مورد استقبال عمومی قرار گرفته است. هدف: مطالعه به منظور معرفی روش جدید الیزا برای جستجوی گلبول های قرمز حاوی محصولات نهایی سیستم مکمل (C3d) به منظور تسهیل بررسی دامنه فعالیت سیستم مکمل و مقایسه آن با C3d آزاد (سرمی) انجام شد. مواد و روش ها: الیزای غیرمستقیم که در اندازه گیری رایج C3d آزاد به کار می رود، به همراه روش...
متن کاملIdentification of C3d receptors on Candida albicans.
Pseudohyphal but not yeast forms of Candida albicans possess both iC3b and C3d receptors, as determined by rosetting with erythrocytes carrying iC3b (EAC3bi) or C3d (EAC3d). Rosetting with EAC3d was markedly reduced when pseudohyphae were heat killed or treated with trypsin or pronase but was not inhibited by several saccharides or aminosaccharides, including alpha-methyl-D-mannoside, or by pre...
متن کاملMutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure.
We recently characterized an interaction between the Staphylococcus aureus immune evasion molecule Staphylococcus aureus binder of Ig (Sbi) and complement C3, an interaction mediated primarily through the binding of C3d(g) to Sbi domain IV. Events related to these studies prompted us to investigate via mutagenesis the binding interface of C3d for Sbi domain IV (Sbi-IV), as well as to revisit th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2000